On Minicircle

post by Metacelsus · 2024-04-23T21:28:51.577Z · LW · GW · 0 comments

This is a link post for https://docs.google.com/document/u/1/d/e/2PACX-1vT7_6kWkIqrvzFZvs88O_NqVzmn-NPINvHOLM-A6r_ieZyvnJsNVk4FSU7EYrePnQg9gT_3kwahJESZ/pub?lsrp=1#h.qso3cw90c5ay

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Max Berry has analyzed Minicircle's follistatin gene therapy, and I agree with his conclusion that it is unlikely to be effective. There are several aspects of their design that could be improved (in particular, using a more efficient lipid nanoparticle delivery system instead of PEI, and making a better choice of promoter). Overall, it seems like they are overcharging for a product of limited value.

I'm posting this here because there has recently been substantial discussion of Minicircle in the rationalist community.

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