How to Get Off the Hedonic Treadmill?

Not sure I can parse "on a hedonic treadmill w/ respect to education, career, significant other" properly. You keep getting better and better education, like people explain things to you more and more clearly, but you don't appreciate the improvement? Or just that you get smarter and smarter, but don't really feel better about it? No matter how high you climb on the corporate ladder, you feel bad about not being Elon Musk? Or is this perhaps about money, like no matter how much you make, there is never enough? Do you keep replacing partners with better and better ones, only to realize that all humans suck? Or is your long-term relationship improving, but after the big problems were solved, now you find yourself irritated with trivialities? Different options possibly require different strategies.

Generally speaking, the strategy for solving the situation of "having it too good, but not feeling satisfied" is to put it in near-mode contrast with having it worse. For example:

• Imagine (in first-person view; try to feel the situation with your senses) how it would feel to not have the education / career / significant other you have now. What would your everyday life be like? You couldn't read the books or web pages you do now, because you would not understand them. You would probably read some celebrity gossip, and believe something stupid like horoscopes. The world would be a very confusing place, and you would seek safety at copying what your neighbors do. Without money, you would not have [list of luxuries you have now]. Without work skills and experience, you would have to take the first available job, probably something unpleasant that would require you to wake up early in the morning, and do something physically demanding. Late in the evening, you would return to your small, empty place (unless you would be living with your parents). Try to imagine living this life, day by day, month by month, year by year. Realize that some people actually have it like this.
• If it is possible to do safely, give up some of the good things temporarily. Turn off the internet for a week. Start fasting. Take a hike in mountains. Spend a few days separated from your significant other.
• Spend some time with people who have it worse than you. Talk with homeless people, whatever. You could join it with some charity work.

In some cases, the right thing to do is to change the game you are playing. If you have great relationship with your significant other, try having kids; this will reset your hedonic threadmill dramatically. Or perhaps stop seeing your career as an unending climb, but give yourself a specific goal, such as early retirement. Maybe you already learned too much, and it's time to start doing something else instead.

Possibly related: some people are maximisers, some are satisficers -- it means that some can't stop looking until they are sure they found the best choice, while for others anything that passes some threshold is acceptable. Generally speaking, the latter are usually much happier in life. Looking for the best option is forever stressful; you can never be 100% sure you found literally the best one; maybe a better one is waiting behind the corner if you only keep looking longer. And finding the best option doesn't even bring much subjective happiness, because if the best option is like 100 points of utility, and the second best is like 98 points of utility, the maximiser will feel like they only gained 2 points. And during the time you spent getting from 98 to 100 points at something, you probably neglected other aspects of your life, where greater improvement was possible. In the meanwhile, a satisficer was like "anything with 90 or more points is good", found the option with 98 points of utility and took it, and proceeded to improve other aspects of their life. Yeah, this is all oversimplifying, but the point is that being obsessed about getting the most can actually reduce your enjoyment of life.

What about other aspects of your life? Health, fame, spirituality, whatever. Maybe if your career and relationships are great, it would make more sense to focus on the remaining parts for a while.