Would be important if it gets replicated. Anyone has a non-gated link?
comment by gwern
· score: 12 (12 votes) · LW
Anyone has a non-gated link?
You can find a link yourself, it's not terribly difficult.
The New Scientist link is dead - the site is spitting out errors for me - so details are a bit hard to find.
But the keywords seem clear; searching 'epigenetics fear mice' in Google Scholar and restricting to 2014 (since this is 'news', after all) shows a number of hits which look likely. The first one is from January and sounds different, but the fifth one is a Nature blurb from December 2014 which is just right; it's paywalled so you can't see the whole thing, but they at least do provide a citation:
Dias, B. G. & Ressler, K. J. "Parental olfactory experience influences behavior and neural structure in subsequent generations". Nature Neurosci. http://dx.doi.org/10.1038/nn.3594 (2013)
which takes us to http://www.nature.com/neuro/journal/v17/n1/abs/nn.3594.html where the abstract sounds correct:
Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2 generations had an increased behavioral sensitivity to the F0-conditioned odor, but not to other odors. When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene. In addition, in vitro fertilization, F2 inheritance and cross-fostering revealed that these transgenerational effects are inherited via parental gametes. Our findings provide a framework for addressing how environmental information may be inherited transgenerationally at behavioral, neuroanatomical and epigenetic levels.
Except this is from 2013. What's going on? Well, re-googling the New Scientist URL, Google snippets says it was published 'Dec 2, 2013', and several other hits were also published Dec 2013. So it seems OP is posting some old news. No matter, it's clearly the right paper.
Paywalled still, though. (The Readcube thing Nature just announced might work, but screw that!) Going back to Google Scholar: GS usually provides the fulltext if available as a little text link in the upper right corner of each hit, and in this case it was just a '[HTML]'. But I've noticed that sometimes they seem to privilege a paywall, and particularly for 'hot' topics with political implications (such as epigenetics) there will often be jailbroken or preprint PDFs on obscure domains which you need to click on 'All n versions' to get a listing of.
In this case, 'All 16 versions' immediately turns up a bunch of PDFs:
The first PDF link is broken, but the second one works and seems like a clean final version.
And if that turned up nothing at all, you could then have gone to Libgen/Scihub, where the paper is already available. This PDF is then easy to copy over to PDF.yt, Dropbox, or you can just link Libgen.
Had the GS PDF links and Libgen both failed, you could have taken the dead PDF links and tried them in the Internet Archive to see if it caught a copy (it often has, if the PDF was visible enough for GS to learn it); if GS/Libgen/IA all fail, you could then try a request on Reddit, and if that failed too, you could try the LW paper request thread. (It's rare for all that to fail for any recent research; if it does, the topic is probably so obscure you will need to either start investing money or simply give up as not worth further effort.)
I hope that will help you find future papers. If you'd like more examples of effective searching, I have a long list of LW examples.
comment by Lumifer
· score: 3 (3 votes) · LW
Thank you. I found the paywalled abstract at Nature, but then stopped. I don't use Google Scholar often enough, maybe I should...