WTH is Cerebrolysin, actually? 2024-08-06T20:40:53.378Z

Comment by gsfitzgerald (neuroplume) on WTH is Cerebrolysin, actually? · 2024-08-13T19:59:05.763Z · LW · GW

Thank you for this additional information! I had not heard of cyclic peptides. To my knowledge, no one has intentionally looked for cyclic peptides in cerebrolysin. However, I think it's pretty unlikely. From what I read about cyclic peptides, they are either derived from natural sources (SFTI-1) or they are synthesized (as in this paper). Synthesizing cyclic peptides involves multiple steps just to get everything to fold correctly. So, it seems unlikely that the random cleavage of brain proteins that occurs in Cerebrolysin synthesis would yield any cyclic peptides.