[Preprint for commenting] Fighting Aging as an Effective Altruism Cause

post by avturchin · 2018-04-16T13:55:56.139Z · score: 24 (8 votes) · LW · GW · 5 comments

"Fighting Aging as an Effective Altruism Cause: A Model of the Impact of the Clinical Trials of Simple Interventions"

Abstract: The effective altruism movement aims to save lives in the most cost-effective ways. In the future, technology will allow radical life extension, and anyone who survives until that time will gain potentially indefinite life extension. Fighting aging now increases the number of people who will survive until radical life extension becomes possible. We suggest a simple model, where radical life extension is achieved in 2100, the human population is 10 billion, and life expectancy is increased by simple geroprotectors like metformin by three more years on average, so an additional 250 million people survive until “immortality”. The cost of clinical trials to prove that metformin is a real geroprotector is $60 million. In this simplified case, the price of a life saved is around 24 cents, 10 000 times cheaper than saving a life from malaria by providing bed nets. However, fighting aging should not be done in place of fighting existential risks, as they are complementary causes.

Highlights:

● Aging and death are the main causes of human suffering now.

● Simple interventions could extend human lives until aging is defeated.

● These interventions need to be clinically tested before FDA approval.

● A trial of the life extension drug metformin is delayed by lack of funds.

● Starting trials now will save 250 million people from death, at a cost of $0.24 for each life saved.

Please comment on the preprint of the article here:

https://goo.gl/WaEYt5

5 comments

Comments sorted by top scores.

comment by ChristianKl · 2018-04-18T06:31:14.222Z · score: 5 (1 votes) · LW · GW

What you write sounds like you consider your credence that metformin has the effect to be 100%. I think Gwern estimated the effect based on the existing literature as less than 1 year, so this doesn't sound reasonable to me.

comment by avturchin · 2018-04-18T09:46:59.489Z · score: 4 (1 votes) · LW · GW

I am going to add the probability that the experiment will prove the life extension effect of the metformin, something like 0.5. However, even if the experiment fails, the start of the experiment will open the ways to other similar experiments, some of which will probably reach success. The main role of the TAME is that it is icebreaker precedent for the future research.

comment by ChristianKl · 2018-04-19T16:47:32.457Z · score: 5 (1 votes) · LW · GW

If you calculate expected value with numbers than it makes sense to use numbers that don't seem fishy. Currently, those in your abstract don't look good.

I reread Gwern and it was a year and not less a year but it was on correlational evidence and most of the time clinical trials find that drugs do less well then expected.

Your paper talks about how Gwern estimates 1 year and you estimate 3 years. It's not clear to me why you use 3 years.

In your article you speak about the cost for a Metformin trials is estimated at $65 million. That's in conflict with the claim in the abstract that it only costs $60 million.

If I remember correctly you also need two trials and not one to get a drug approved by the FDA. If the $65 million is actually for two trials, say so, otherwise you should calculate more costs for getting Metformin approved than the $65 million.

What's the outside view of phrase III trials showing that a drug does what the creator wants? I would guess that it's less than 0.5, so those seem optimistic as well.

GiveWell generally tries to use conservative numbers and I think your case would benefit from also using more conservative numbers even if it means that the cost per live saved rise by an order of magnitude.

comment by avturchin · 2018-04-19T19:13:29.381Z · score: 4 (1 votes) · LW · GW

3 years was the estimation of the expected effect by the main experimenter behind TAME - Nick Barzilai. This is what he expects to see. But I think more conservative will be to use Gwern's estimation of 1 year, and I will turn to this estimate.

Theres is, in fact, another smaller trial of metformin for life extension called MILES, but it is not longitudinal study, just 3 weeks, but it has funding and preliminary FDA approval. Thus if TAME will happen, there will be two studies.

I am going to add the probability of success in the next version of the estimation and update the price of study (they told that they collected part of the money).

comment by avturchin · 2018-04-19T19:20:14.286Z · score: 4 (1 votes) · LW · GW

I don't understand your comment - is it advertising of the publishing service or come considerations about aging?