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I have been working on value alignment from systems-neurology and especially adolescent development for many years, sort of in parallel with ongoing discussions here, but in terms of moral isomorphisms and autonomy and so on. Here, a brief paper from a presentation for the Embodied Intelligence conference 2023 about development of purpose in life and spindle neurons in context of self-association with religious ideals, such as we might like a religious robot to pursue, disregarding corrupting social influences and misaligned human instruction, and so on: https://philpapers.org/rec/WHIAAA-8 I think that this is the sort of fundamental advance necessary.
The best argument that we are in a simulation is mine, I think: https://link.springer.com/article/10.1007/s00146-015-0620-9