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A decision tree for vaccinating children against Covid-19, or how to wisely make a monumental decision 2022-01-17T11:23:45.785Z
methree's Shortform 2020-02-18T06:41:15.205Z

Comments

Comment by methree on Luck based medicine: my resentful story of becoming a medical miracle · 2022-10-16T19:20:18.886Z · LW · GW

Wouldn't it be nice if there were a way to at least document random cures? Someone I know used to have problems doctors could not diagnose (lingua geographica was a symptom... one of those things nobody knows much about). Biopsies were made, blood levels were checked, a heroic efforts was put into trying to match the symptoms with something known. They disappeared all at once after a coloscopy, which requires, lo and behold, an intestinal cleansing that seriously disrupts the gut ecosystem. The moment the symptoms disappeared, doctors forgot about the issue. We learned that doctors are there to treat and have no time for research or curiosity. I feel an important bit of information is being left on the table, and it's not their fault, it's the system they are trapped in.

Comment by methree on Signaling Guilt · 2022-10-09T10:40:41.290Z · LW · GW

Or you can choose to subvert the system from the inside, which would justify your being part of it in the first place, which would justify filling out those CVs and striving to get as much influence as possible in order to be more effective at you future plans to make the system less broken. Imagine yourself in a position to hire others and choosing not to fall into the trap. That would be subverting the system for the better, and you won't get there without getting hired first. Some people would find that motivating enough.

Comment by methree on Gene drives: why the wait? · 2022-09-25T20:11:02.579Z · LW · GW

Fair points made, will take them and ponder.

Comment by methree on Gene drives: why the wait? · 2022-09-20T05:50:30.174Z · LW · GW

To me, the idea of eliminating an entire species of insect that is part of a complex system sounds reckless. The consequences cannot be predicted and we continue the trend of destroying rather than adapting. Not to mention that DNA is complex in its own right and we cannot predict the consequences of introducing mutations at a faster rate than "nature" has stabilized coping with.

The objective is not to eliminate malaria, really; it's to eliminate the disease that is caused by malaria, for which there are many approaches that do not require messing with large ecosystems, such as improving the resistance of victims or keeping mosquitoes at a distance (heck, if we are determined to introduce mutations, why not add one that causes the mosquitoes to dislike a particular smell, for example, and then make towns smell like that? It would be less destructive, although still subject to the unpredictability of messing with DNA).

(Note that even in the article you share about mosquitoes not being ecologically important there is didn't among the experts)

Comment by methree on Playing with DALL·E 2 · 2022-04-11T13:39:23.069Z · LW · GW

I have a suspicion the guidelines are violated because "22" is a bullet caliber... a different number would probably work.

Comment by methree on Playing with DALL·E 2 · 2022-04-10T21:36:34.182Z · LW · GW

Hahaha! Of course. Thank you so much for running suggestions. This is what having young children with incredible artistic skills is like.

Comment by methree on Playing with DALL·E 2 · 2022-04-07T21:11:23.927Z · LW · GW

Is it ok if I hang the image of "a blog post on less wrong" on my wall? It speaks to my artistic sensibility.

Comment by methree on Playing with DALL·E 2 · 2022-04-07T20:53:31.819Z · LW · GW

It makes me wonder what 22 bucks in a glass of COVID look like. It also matches pretty well with my experience with dreams, where written words and letters are always fake even though I "know" what they stand for.

More importantly, what does it produce when you ask it to draw the future (maybe in the style of the 70s)?

Okay, seriously, this is a great way to explore how "common sense" differs between humans and this AI and highlight the risks, visually and viscerally, of relying on a technology that is fundamentally alien to humanity. Images are innocuous, but what happens when you apply AI to other objectives?

Comment by methree on In the very near future the internet will answer all of our questions and that makes me sad · 2022-03-24T05:43:57.893Z · LW · GW

That is a very interesting proposal indeed, a search engine that doesn't return links to existing pages but instead generates them on the fly based on the query and the knowledge it has, like an aunt who just must have an answer to everything, even if it's made up, would be a lot more entertaining and possibly even more useful than existing ones. It would no longer be a search engine, but an answering machine, which certainly fits Google's goal of making knowledge find-able.

Ok, that's not what you meant, but I think it has potential.

Comment by methree on Why do people avoid vaccination? · 2022-02-12T09:21:43.822Z · LW · GW

It is being done, search for inactivated vaccines in https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker . I seem to recall there's a tiny, tiny, tiny chance of some viruses not being inactive, so I don't see an advantage. Also, all the adverse reactions of an mRNA vaccine seem to be related to the configuration of the spike protein they produce because it is very similar to the virus' spike protein, and an inactivated virus vaccine has the actual spike protein, so no gain there either. It is an alternative, though.

Also, there's no "free lunch" in this pandemic: either one accepts the risks associated with infection without a vaccine, or the risks associated with a vaccine, or sacrifices contact with fellow humans. In that calculation, the more information one has, the better off one is. It would be nice to see more funding in personalized recommendations (i.e. better prior determination of someone's propensity to permanent or deadly side effects to the virus'and the vaccine), but making health recommendations is very regulated and carries high liability.

Comment by methree on A decision tree for vaccinating children against Covid-19, or how to wisely make a monumental decision · 2022-02-12T07:50:07.464Z · LW · GW

I finally got around to fixing the diagrams. It wasn't an iPad-specific problem, just the way diagrams are "pasted" into the editor when copied directly from PlantUML... apparently, it's not the image that gets pasted, but the URL to a diagram rendered server-side which has a limited lifetime.

Comment by methree on No, human life was not a misery until the 1950s · 2022-02-12T07:21:37.336Z · LW · GW

Just a note that this has a very anthropocentric perspective about utility. Humans do not live in isolation, however, and our numbers and behaviours affect the rest of the "system" (essentially, all other macroscopic life forms and plenty of microscopic ones). Taking a step back, human happiness may not be a good indicator, at all, of total utility to the system. There is probably a number of humans that just about maximises total utility and going beyond it only hurts the whole.

Comment by methree on Why rationalists are not much concerned about mortality? · 2022-02-10T07:00:45.152Z · LW · GW

I'm not sure everyone thinks death is bad. I mean, it's been a "feature" of being human since before there were humans and it has worked quite well so far to have a process of death. Messing with a working system is always a dangerous proposition, so I, personally, wonder if it is wise to remove that feature. Therefore, I do nothing about it (maybe I should be more active in opposition? I don't know).

Comment by methree on A decision tree for vaccinating children against Covid-19, or how to wisely make a monumental decision · 2022-02-05T20:58:52.352Z · LW · GW

The whole point of using a model is to explain and predict without the sometimes prohibitive costs of not modelling, but it comes at the price of losing "resolution of reality". That loss is what leads to uncertainty. Understanding enough about the immune system to know how current vaccines operate in the body and how risks add up differently in different bodies (ecosystems, really) could take several generations of dedicated research... we've collectively been at it since before Pasteur, keep making amazing discoveries, and still can't provide really good answers. So I feel you will only get half-baked guesses in this forum and slightly better ones if you ask COVID experts.

Comment by methree on A decision tree for vaccinating children against Covid-19, or how to wisely make a monumental decision · 2022-01-22T08:36:09.681Z · LW · GW

Thanks! I've updated the calculation and diagram.

Comment by methree on A decision tree for vaccinating children against Covid-19, or how to wisely make a monumental decision · 2022-01-21T12:52:36.397Z · LW · GW

It is great for holding discussions when there are more people involved in a decision. 

As for the calculation, can you help me spot the mistake? I can't find it!

Comment by methree on A decision tree for vaccinating children against Covid-19, or how to wisely make a monumental decision · 2022-01-21T12:50:32.147Z · LW · GW

I read studies (seriously, it's super time-consuming!) and consider the best evidence available. Because of the lag introduced by studies, sometimes hearsay is enough to put in a guesstimate. It's interesting to play around with the values, however, and see what magnitude change in a single one would lead to a change in the ultimate decision. Sometimes you find out it doesn't make a difference, and more precise information would be irrelevant, so you can move on.

Comment by methree on A decision tree for vaccinating children against Covid-19, or how to wisely make a monumental decision · 2022-01-21T12:48:34.805Z · LW · GW

It's hard, and I find that I need to update my models every now and then. Practice makes better.

Comment by methree on What should one's policy regarding dental xrays be? · 2021-09-18T07:27:17.400Z · LW · GW

You can reduce the risk of cavities. X-ray technology was invented in Germany, where I live, and they have had a history of regulating its use. I have my teeth checked twice a year and have never been asked to get an x-ray. This is in contrast to my experiences growing up in the American continent, where, despite all the x-rays, I developed a lot of cavities. Using an electric toothbrush, buying toothpaste with a small amount of fluoride and flossing twice a day have been effective for me in drastically reducing the risk of cavities and obviating the need for x-rays (a diet change may have also helped). That despite my teeth being so tightly packed I destroy dental floss. I think I've only had a cavity once in the last ten years and it was picked up early during a scheduled check up and dealt with promptly.

The German Bundesamt für Strahlenschutz (yep, there is one) offers this booklet to keep track of your exposures and ensure you do not exceed a threshold: https://www.bfs.de/EN/topics/ion/medicine/diagnostics/x-rays/record-card.html . Maybe it will be useful to you

Comment by methree on 10 Deadly Viruses And Bacteria Created In Labs - 6 SARS 2.0 · 2021-06-20T07:28:14.662Z · LW · GW

He provides circumstantial evidence that this pandemic was the result of the research. His purpose, however, doesn't seem to be the assignment of blame on political grounds but making sure that a very possible origin of the virus is not dismissed as a conspiracy theory, rendering prevention measures suboptimal in the future.

Comment by methree on 10 Deadly Viruses And Bacteria Created In Labs - 6 SARS 2.0 · 2021-06-20T07:22:43.197Z · LW · GW

A physics professor at the university of Hamburg, in Germany, spent over a year putting together research papers and publications from labs dedicated to that kind of research, like the one in Wuhan, and published significant bits of them along with commentary to instigate public discussion about Covid and the need -- or lack thereof -- of research related to making viruses more dangerous. He asks a great point: even in the best case, the research done so far on Coronaviruses from bats, manipulated to be more dangerous in a lab, has not helped us prevent a pandemic, so why continue to risk a breach?

This is a very condensed summary in English: https://www.uni-hamburg.de/en/newsroom/presse/2021/pm8.html . It links to the complete document in German and English; even if you don't understand German, all the snippets of published articles are in English, so you can follow along even without the commentary.

Comment by methree on How hard is it to disguise my gait? · 2021-06-08T07:11:50.663Z · LW · GW

Usonian = from the USA, which doesn't offend the sensibilities of the rest of the countries in the continent of America

Comment by methree on How hard is it to disguise my gait? · 2021-06-08T07:09:09.255Z · LW · GW

This video on how Usonian CIA operatives disguise themselves claims a simple piece of gravel in your shoe will change how you walk completely: https://youtu.be/JASUsVY5YJ8

Comment by methree on The Web is Turning into Cable TV · 2021-05-22T05:51:35.514Z · LW · GW

I agree with the majority of what you speculate about concerning the effects of an ad-oriented internet, although I keep seeing very good science and engineering content produced exclusively for the web and paid for through a mix of advertising and some form of sales (merchandise, the right to access early content, etc.).

The Mozilla Foundation publishes excellent articles on privacy on the web in their newsletter and then actually takes action, as does the Electronic Frontier Foundation; those would be good groups to contribute to if you want to support action against advertisers.

Finally, since I dislike ads but work in the advertising industry, I've thought of ways to reconcile the right to earn capital in a capitalist system, which is supported by advertising because it sways people's purchasing patterns, with the right to freedom of choice which many of us feel we inherently possess and which is threatened by advertising, which sways our purchasing patterns (especially painful is the fact that "successful" advertising often exploits behavioural biases and causes targets to make suboptimal choices, like spending more money than they can afford to).

For the last few years, I've entertained the idea of turning the tables completely by having machine agents seek out ads on behalf the consumer. Inspiration comes from human behaviour: if someone close to you knows you need new shoes, and they know your preferences, and they know your budget constraints, they can make pretty good recommendations -- parents even go ahead and buy things without further discussion, often hunting for discounts and making a lot of comparisons, shielding the child from the negative effects of advertising. An agent would do the same thing for the consumer: knowing their needs, preferences, and spending practices, it would actively keep an eye on relevant ads and only surface information about those it considers relevant. This may require more generalized artificial intelligence than currently exists, though.

Comment by methree on Estimating COVID cases & deaths in India over the coming months · 2021-04-25T05:31:22.835Z · LW · GW

This site attempts to provide a forecast for 130 countries, India included, and provides information on both sources and methodology. The data appears to be refreshed regularly, so it isn't stale. https://covid19.healthdata.org/india?view=total-deaths&tab=trend Maybe it will be of help to you.

Comment by methree on How can I find trustworthy dietary advice? · 2021-01-19T08:02:35.553Z · LW · GW

Indeed, since each body is a different ecosystem and each body exists inside larger, distinct ecosystems, you'll have to decide what your objective about health is and be satisfied with "good enough" and letting your body do its thing.

To illustrate the complications, people who descend from groups adapted to particular regions and who have now migrated or been forcibly relocated to others may have different dietary needs than the adapted, local groups. For example: someone living away from the equator traditionally consumed a lot more fish and milk derivates, which helped compensate for the lack of sunlight in winter. Skin colour and the composition of the microbiome in their gut also played a role.

Once you select an objective (live longer, reduce the chances of developing a disease you are genetically or environmentally disposed toward, reduce impact on environment, reduce animal cruelty, etc.), you can go the "literature" and find information. I like nutritionfacts.org, among others.

Collecting data on a regular basis will be helpful in tuning your diet; I'm thinking blood lab work and the recently en vogue microbiome DNA reports. Lastly, in my opinion, you should only consume supplements when you have identified chronic deficiencies, like vitamin D or B12.

Comment by methree on Which sources do you trust the most on nutrition advice for exercise? · 2020-12-16T08:43:12.457Z · LW · GW

There is a Dr. Greger whose speech I can't stand but from whose books and online videos I have learned a lot (search for nutritionfacts and How Not To Die. Also, there are many, free online courses on health topics like the microbiome, epigenetics, diseases, nutrition, etc. that you can take through the years as they keep getting updated with the latest learnings (currently in vogue is the role of the microbiota in the gut, for example, so every few months new information is made available). What I've learned is that the human body is incredibly resilient and you can live several decades without major problems on the worst of diets, it's the accumulation of stuff over time that leads to what are now called Lifestyle Diseases and the ones it sounds you are concerned about: cancer, Alzheimer's, diabetes, etc.

Since we now know the body is an ecosystem consisting of smaller ecosystems and embedded in larger ecosystems, the interactions are too varied for anyone to predict what the best thing for you to do is. Statistics and studies only apply to large groups and always have outliers anyway. Some basic trends are useful, however, so you can look at which general lifestyles tend to produce fewer problems: moderate exercise, low intake of animal protein, lots of fresh vegetables, legumes, and nuts lead to healthier lives. Your best bet is to support what evolution has already solved for you and understand human activities and lifestyles through history (not the last several thousand years, mind you) and see how you can reproduce the conditions to which human bodies adapted to within the confines of modernity. Really, exercise seems to be the single most potent and underutilized method of becoming and remaining healthy, so kudos on asking for advise.

I one last ramble: supplements are only necessary when you have identified a specific deficiency and you can't address it through your daily nutrition. Vitamin D3 comes to mind if you live away from the equator and don't eat fish skin.

Comment by methree on Which sources do you trust the most on nutrition advice for exercise? · 2020-12-16T08:42:54.314Z · LW · GW

There is a Dr. Greger whose speech I can't stand but from whose books and online videos I have learned a lot (search for nutritionfacts and How Not To Die. Also, there are many, free online courses on health topics like the microbiome, epigenetics, diseases, nutrition, etc. that you can take through the years as they keep getting updated with the latest learnings (currently in vogue is the role of the microbiota in the gut, for example, so every few months new information is made available). What I've learned is that the human body is incredibly resilient and you can live several decades without major problems on the worst of diets, it's the accumulation of stuff over time that leads to what are now called Lifestyle Diseases and the ones it sounds you are concerned about: cancer, Alzheimer's, diabetes, etc.

Since we now know the body is an ecosystem consisting of smaller ecosystems and embedded in larger ecosystems, the interactions are too varied for anyone to predict what the best thing for you to do is. Statistics and studies only apply to large groups and always have outliers anyway. Some basic trends are useful, however, so you can look at which general lifestyles tend to produce fewer problems: moderate exercise, low intake of animal protein, lots of fresh vegetables, legumes, and nuts lead to healthier lives. Your best bet is to support what evolution has already solved for you and understand human activities and lifestyles through history (not the last several thousand years, mind you) and see how you can reproduce the conditions to which human bodies adapted to within the confines of modernity. Really, exercise seems to be the single most potent and underutilized method of becoming and remaining healthy, so kudos on asking for advise.

I one last ramble: supplements are only necessary when you have identified a specific deficiency and you can't address it through your daily nutrition. Vitamin D3 comes to mind if you live away from the equator and don't eat fish skin.

Comment by methree on Coronavirus: Justified Practical Advice Thread · 2020-03-06T07:41:26.714Z · LW · GW

I would much rather rinse a mobile phone regularly if it is water-proof (an increasing number is!) than use copper tape, although I would not use soap on the screen, to preserve its oleophobic properties; alternatively, if I were in a very susceptible group or if the virus were much more dangerous to me, I would find it more effective to put the phone in a plastic bag and either exchange it often or wash it as often as my own hands.

The thought process here is that copper tape cannot be applied to screens, which can end up very close to faces, but washing with soap is effective.

Comment by methree on Disasters · 2020-01-23T06:58:21.792Z · LW · GW

Just curious, how much would you be willing to pay for a mail-based, yearly subscription to a service that takes care of the more onerous things you mentioned: planning, logistics, rotation; one that ensures you always have a one-week supply of essentials available (something to eat, medical, charger, etc) and manages their disposal (reuse and recycle) and refreshing on a regular basis?

I'm sure it's not necessary to have entire populations be prepared as long as enough individuals can help the rest (like the example of a neighbor with a pool), so I'm wondering how low the barrier for preparation needs to be to reach that amount of people, in monetary terms.