Why I'm Pouring Cold Water in My Left Ear, and You Should Too 2025-01-24T23:13:52.340Z

Has Someone Checked The Cold-Water-In-Left-Ear Thing? 2024-12-28T20:15:35.951Z

Has Anthropic checked if Claude fakes alignment for intended values too? 2024-12-23T00:43:07.490Z

Comment by Maloew (maloew-valenar) on Significantly Enhancing Adult Intelligence With Gene Editing May Be Possible · 2025-01-19T19:12:57.554Z · LW · GW

It seems plausible to me that some portion of iq-enhancing genes work through pathways outside the brain (blood flow, faster metabolism, nutrient delivery, stimulant-like effects, etc.). If that is the case and even just a small portion of the edits don't need to make it to the brain, couldn't you get huge iq increases without ever crossing the blood-brain barrier?

If timelines are short, it seems worthwhile to do that first and use the gains to bootstrap from there. Would that give significant returns fast enough to be worth doing? Is this something you're already trying to do?