Posts

How to make food/water testing cheaper/more scalable? [eg for purity/toxin testing] 2024-03-23T05:28:17.273Z
How do you improve the quality of your drinking water? 2024-03-13T00:37:40.389Z
Will posting any thread on LW guarantee that a LLM will index all my content, and if questions people ask to the LLM after my name will surface up all my LW content? 2023-08-11T01:40:10.933Z
How do I find all the items on LW that I've *favorited* or upvoted? 2023-08-07T23:51:05.711Z
Alex K. Chen's Shortform 2023-08-07T17:06:18.876Z
What can people not smart/technical/"competent" enough for AI research/AI risk work do to reduce AI-risk/maximize AI safety? (which is most people?) 2022-04-11T14:05:33.979Z

Comments

Comment by Alex K. Chen (parrot) (alex-k-chen) on An Exploratory Toy AI Takeoff Model · 2024-06-10T03:53:35.952Z · LW · GW

Why is thing IQ measuring mostly lognormal

Comment by Alex K. Chen (parrot) (alex-k-chen) on Drexler's Nanosystems is now available online · 2024-06-03T00:54:57.582Z · LW · GW

Worth following for his take (and YouTube videos he is creating): https://x.com/jacobrintamaki

[he's creating something around this]

Comment by Alex K. Chen (parrot) (alex-k-chen) on Alex K. Chen's Shortform · 2024-05-31T02:42:36.359Z · LW · GW

What are your scores on the US Economic Experts Comparison (Interactive Matrix)?

https://www.kentclarkcenter.org/economist-comparison-interactive-matrix/

Comment by Alex K. Chen (parrot) (alex-k-chen) on Notes on Gracefulness · 2024-05-29T07:14:45.720Z · LW · GW

How about people who just don't "give a fuck", are Nishkama Karma, and maintain emotional composure even in times when others doubt them/do not believe them (knowing that the end is what matters).They are graceful on the inside, and maintain internal composure in the face of chaos, but others may view their movements as ungraceful particularly b/c they have the sense (and enough of a reality distortion field) to "make the world adapt to them", rather than "adapt to the world" (if they succeed, they make the world adapt to them such that the world around them becomes more harmonious long-term after the initial reduction in harmony [due to the clumsiness of the world learning to adapt to them]). It takes time to learn grace, and when choosing the ordering of vital skills to learn, grace is often learned later than skills one has comparative advantage in.

[as an example, I know I have historically been ungraceful when reacting to my own dumb mistakes. I do it to signal awareness/remorse, but in an overly emotional way that may cause some people to doubt my emotional stability near-term].

[in the long run, learning to read a room is one of the best ways of developing grace, though it matters more if one is ultra-famous than when one is mostly unknown and can afford to experiment with consequence-free failure]

(asking questions that appear dumb to some people can also be "ungraceful" to the audience, even if important. the strategic among that crowd will just have good enough models of everyone to know who the safest people are to ask the "dumb questions" to)

Sometimes, the fastest way to learn is to create faster feedback loops around yourself ("move fast and break things"). The phrase "move fast and break things" appears disharmonious/ungraceful, but (if done in a limited way that "takes profits" before turning into full-blown mania), can be one of the fastest ways of achieving a more harmonious broader state, even when creating some local chaos/disharmony.

People who appear to have high levels of grace can also be extremely dangerous because they can get people to trust them to the very end, especially if their project is an inherently destabilizing project. Ideally, you want a 1-1 correspondence between authenticity/robustness/lack of brittleness and grace, but people's perception of gracefulness at all levels is not high enough for the perception of gracefulness to be the most reliable perception.

Having grace often means doing "efficient calculations" without being explicit about these calculations. It's like keeping your words to yourself and not revealing your cards unless necessary (explicit calculations are clumsy/clunky). Sometimes, a proper understanding of Strauss is necessary to develop grace in some environments (what you say is not what you really mean, except to the readers who have enough context to jump all the layers of abstraction - it may also be needed to communicate unobvious messages in environments where discretion is important)

Patience is also grace (and not getting into situations that cause you to "lose control"/be impatient/exciteable/manic OR do things out of order). At the same time, there are ways of turning a reputation of ditching meetings into gracefulness (after all, most meetings do last longer than needed, as Yishan Wong once mentioned) [some projects also require a high deal of urgency, potentially including eras of accelerated AGI timelines]

Having the appearance of "whatever happens, happens" is graceful. Being able to keep a poker face is graceful. Not acting in distress/pain in order to gain people's sympathy is graceful. As someone who knows many in the longevity community, I know that having the appearance of "fearing death" or "wanting to live forever" is super-ungraceful (and gives PR image problems in its ungracefulness). There are some people in longevity who are closet immortalists who can appear graceful because they don't appear as if they care that much about whether or not they live forever. In a similar way, doomerism about AI is extremely ungraceful (though those who are closeted doomers/immortalists can sometimes be secretly graceful to those who are less closeted about these things).

Things that are not the most graceful: over-correcting/over-compensating, irritability, appearing emotional enough to lose control, constantly seeking feedback (implies lack of confidence), visibly chasing likes, obsessing over intermediate computations/near-term reinforcement loops, "people pleasing" (esp when one is obvious about it), perseverating, laughing at one's own jokes, not being steadfast, not knowing when to stop (autistics are prone to this..), going for the food too early (semaglutide can help with grace..) Autistic people often lack grace, though some are able to develop it really well over long timescales.

Grace is having confidence over the process without becoming too attentive to short-term reinforcement/feedback loops (this includes patience as part of the process).

As with everything else, intelligence makes grace easier (and makes it possible to learn some things gracefully), but there is enough variation in grace that one can more than make up for lower intelligence with context+grace+strategic awareness. There is also loss of grace with older ages as working memory decline can increase impatience (Richard Posner said writing ability is the last to go, but that's because there's no real time observation of the process, and there's grace in observing the dynamics).

Comment by Alex K. Chen (parrot) (alex-k-chen) on on the dollar-yen exchange rate · 2024-05-26T07:35:23.080Z · LW · GW

Wow, and Mexico's fertility rate just plunged to 1.82

Comment by Alex K. Chen (parrot) (alex-k-chen) on simeon_c's Shortform · 2024-05-25T09:41:46.149Z · LW · GW

Isn't that a non-disparagement clause, not a NDA?

Comment by Alex K. Chen (parrot) (alex-k-chen) on An Exploratory Toy AI Takeoff Model · 2024-05-25T03:57:16.655Z · LW · GW

This is a very promising start on some thesis (that could go further into the theory of computation/sid mani content/https://lifeiscomputation.com/), but the "intelligence growth curves" are not very intuitive. I wager that dimensionality is more important than number of elements in determining intelligence growth curves and especially number of discontinuous jumps.

Why does F^4_65's intelligence peak out at such a low value at time 2040? Why does 's intelligence peak out at a lower value than equal-dimensional fields with fewer elements in them?

at some point it may have to incorporate quality/diversity/taste, not just size

Comment by Alex K. Chen (parrot) (alex-k-chen) on Which skincare products are evidence-based? · 2024-05-24T19:13:09.616Z · LW · GW

Has anyone tried Visia skin analysis to get feedback loops on skinhealth? (they reveal WAY more than just pictures) The problem with camera images is that visible light doesn't capture fine lines or wrinkles. My skin SEEMS to look as perfect as that of a 12-year old on the outside, but there is some small amount of wrinkling under my eyes that a visia reveals (which is why this thread prompted me to finally get dermatica tretonin) 

Collagen peptides also can help increase collagen synthesis and relieve fine lines (it's my biggest pet peeve b/c I can't stand ingesting animal products, and this is the only thing Bryan Johnson will ditch veganism for). And it's really irritating that there isn't more vegan collagen available. 

Comment by Alex K. Chen (parrot) (alex-k-chen) on Advice for Activists from the History of Environmentalism · 2024-05-23T05:01:02.736Z · LW · GW

Newt Gingrich started out as an environmentalist (and a former member of the Sierra Club), but later turned away from it.

Even after he left congress, he still had some sympathy for environmental issues, as he wrote the book "Contract with Earth" (with an EO Wilson forward). 

Newt can be surprisingly high openness - a person oriented towards novelty can be pro-drilling (accel), pro-geoengineering, and pro-environment (which can be decel), and maybe not reconcile the two together in the most consistent way. He has been critical of both parties on climate change/environment issues (just as Mitt Romney has been, who scores low on the LCV but who really does care about addressing climate change, just not in the "punitive" way that the Democrats want to see it addressed). Free-market environmentalists who do care have different approaches that might on the surface be seen as riskier (just as making use of more energy gives you more resources to address the problem faster even while pumping more entropy into the system).

But his high openness (for a Republican) seems to have also made him more stochastic, or inconsistent.

The book generated a storm of media attention in late 2007 and early 2008 as the U.S. presidential campaign began to heat up. Gingrich in particular made numerous media appearances arguing that the Republican Party was losing popular support because their response to environmental policy was simply, as he put it, "NO!" Maple toured the country as Gingrich's stand-in, most notably before the Republicans for Environmental Protection (REP, www.repamerica.org) during their annual meeting (at which John McCain was endorsed as the most "green" of the Republican presidential candidates). In 2008 Gingrich published another book that advocated oil drilling, Drill Here, Drill Now, Pay Less, and many pundits called his environmental commitment into question. However, this book's fifth chapter provided an argument for environmental protection. Like many aspects of Gingrich's career, his interest in environmental issues has generated controversy.

https://archive.ph/LsZeh

Ronald Reagan was surprisingly pro-environment as governor of California (Gavin Newsom even spoke about it when he visited China), but later was seen as anti-environmental by environmental groups as president (esp due to his choices of Secretary of the Interior and https://www.cnn.com/2024/01/17/politics/supreme-court-epa-neil-gorsuch-chevron/index.html ) and his generally pro-industry choices. George H.W. Bush was surprisingly pro-environment in his first 2 years (ozone, acid rain..), but was advised to no longer be pro-environment b/c it would not sit well with his base..

worth reading: https://kansaspress.ku.edu/blog/2021/10/13/when-democrats-and-republicans-united-to-repair-the-earth/

===

the LCV seems to take the view that all drilling/resource extraction (or industry) is bad. But it still is done somewhere, and if not done in America, it's just outsourced elsewhere (eg https://time.com/6294818/lithium-mining-us-maine/), where it is done with lower standards that cause more local destruction to the environment/pollution (albeit not the kind that Americans feel).

See https://www.energypolicy.columbia.edu/qa-the-debate-over-the-45x-tax-credit-and-critical-minerals-mining/

====

Now that CA appears likely to pass SB-1047, it seems more probable that Republican states will go against it (simply because they, esp Desantis [who valorizes not being CA], want to "own the libs" - esp as @BasedBeffJezos notices). 

====

https://www.politico.com/newsletters/power-switch/2024/06/26/what-curtis-victory-in-utah-means-for-climate-00165123 is a possible source of hope when a new Trump presidency may potentially gut much of the EPA and many other environmental regulations... Republican voices for the environment have especially high leverage during a time when Trump focuses much of his platform as the negation of the "other side" (just as he wants to revoke Biden's EV mandates and Biden's executive order on AI).

https://www.latimes.com/environment/newsletter/2024-01-18/column-meet-john-curtis-the-utah-republican-who-cares-about-climate-change-boiling-point

===

I once saw a graph showing which counties in the US believed that climate change came from humans... It strongly corresponded with partisan affiliation, though somewhat less in WA and CA - the two states where more than 50% in many red counties believed that it did... Source here: 

===

IFP (which has some writers who seem more right-wing than left-wing) has a lot to say on the cost-benefit analysis of environmental regulation. NEPA has done a lot to slow down all forms of infrastructural development, and made projects of ALL kinds move much more slowly. But IFP also recognizes the positive externalities of reduced pollution levels. 

Comment by Alex K. Chen (parrot) (alex-k-chen) on What comes after Roam's renaissance? · 2024-05-18T06:37:50.617Z · LW · GW

There's tana https://twitter.com/AndyAyrey/status/1791679301362016519?t=Wo8e4NcWJqY4pcHRjMYgAQ&s=19

Comment by Alex K. Chen (parrot) (alex-k-chen) on True Stories of Algorithmic Improvement · 2024-05-16T01:10:13.907Z · LW · GW

Now AlphaTensor - https://deepmind.google/discover/blog/discovering-novel-algorithms-with-alphatensor/

Comment by Alex K. Chen (parrot) (alex-k-chen) on Environmentalism in the United States Is Unusually Partisan · 2024-05-14T22:59:47.059Z · LW · GW

Bill Frist, the former Republican Senate Majority Leader under Bush (even though he had a low score by the partisan/zero compromises LCV), is now chairman at the Nature Conservancy (it's even his LinkedIn profile header) and frequently speaks out on environment and climate change issues. His kind of Republicanism is now way out of vogue.

https://www.tennessean.com/story/news/2022/08/16/tenneessee-former-senator-bill-frist-elected-chair-nonprofit-nature-conservancy/10328455002/

https://www.linkedin.com/posts/billfristmd_nature-conservation-activity-7114961629628227585-C5BY?utm_source=share&utm_medium=member_android

Republicans from Utah seem to disproportionately form the Republican climate change caucus - they tend to be somewhat more open-minded than Republicans elsewhere, and some of the current representatives have been outspoken on the need to combine conservation with conservatism (though this also means making some compromises with federal land ownership which has become an unusually partisan "don't compromise" issue). 

Comment by Alex K. Chen (parrot) (alex-k-chen) on What comes after Roam's renaissance? · 2024-05-14T22:52:57.042Z · LW · GW

No one mentioned Remnote? It's the one Roam replacer that seems to beat Roam on many of the things it was good at. 

I way prefer remote storage, having lost a hard drive before, so I don't like Obsidian much. 

Comment by Alex K. Chen (parrot) (alex-k-chen) on The Cognitive-Theoretic Model of the Universe: A Partial Summary and Review · 2024-04-21T15:31:34.107Z · LW · GW

Related "As stated, one of the main things I make-believe is true is the overlighting intelligence with which I align myself. I speculate that I am in a co-creative relationship with an intelligence and will infinitely superior to my own. I observe that I exist within energetic patterns that flow like currents. I observe that when I act in alignment with these subtle energetic currents, all goes well, desires manifest, direction is clear, ease and smoothness are natural. I observe that I have developed a high degree of sensitivity to this energy, and that I’m able to make micro-corrections before any significant non-smoothness occurs.""

https://cosmos.art/cosmic-bulletin/2020/marco-mattei-cosmopsychism-and-the-philosophy-of-hope roon once said "we are all a giant god dream"

Comment by Alex K. Chen (parrot) (alex-k-chen) on Thoughts on seed oil · 2024-04-21T02:18:37.343Z · LW · GW

It depends on how processed the PUFA is - many PUFAs in processed foods are highly heated up. Processing PUFAs in high heat is what causes peroxidizeable aldehydes/acrolein/9-HNE/advanced lipid peroxidation end-products (ALEs)/etc

But PUFAs in soybeans (or sunflower seeds w/o extra procesing) themselves are way less likely to be bad, and this is what the epidemiological evidence hints at.

For whatever reason, PUFAs are VERY strongly protective against heart disease (b/c they lower LDL) and insulin resistance. These are the leading causes of death on western populations, but this does not make PUFAs equally protective on all diseases, especially those who already have very low risk of death from heart disease/insulin resistance.

Fish oil (omega-3's) are also WAY more easily damaged/peroxided than even omega-6's. People usually don't fry food with omega-3's the way they do with omega-6's, but if they did, would we see the opposite association with omega-3's that we usually see? [note omega-3's still fail to increase lifespan as per ITP]

What I am concerned is if they change cell membrane composition long-term in a way that makes cell membranes more easily peroxidized (animals with more saturated lipid membranes live longer, though there are ways to fix the damage, as Gustavo Barja knows - Longevity and Evolution (Aging Issues, Health and Financial Alternatives) 1 )

Whether omega-6's convert into pro-inflammatory or anti-inflammatory metabolites of arachidonic acid (BOTH are possible) depends highly on one's D6D genotype.

more info I collected: https://www.crsociety.org/topic/18298-are-omega-6s-healthy-or-really-bad-or-does-it-depend-on-how-theyre-processed-and-d6d-genotype/#comment-45956

Comment by Alex K. Chen (parrot) (alex-k-chen) on All About Concave and Convex Agents · 2024-03-31T01:09:45.929Z · LW · GW

https://vitalik.eth.limo/general/2020/11/08/concave.html

Comment by Alex K. Chen (parrot) (alex-k-chen) on The Cognitive-Theoretic Model of the Universe: A Partial Summary and Review · 2024-03-28T22:05:50.441Z · LW · GW

I view a part of this as "maximizing the probability of the world to enable "God's mind" to faithfully model reality [1] and operate at its best across all timescales". At minimum this means intelligence enhancement, human-brain symbiosis, microplastics/pollution reduction, reduction in brain aging rate, and reducing default mode noise (eg tFUS, loosening up all tied knots).

The sooner we can achieve a harmonious global workspace, the better (bc memory and our ability to hold the most faithful/error-minimizing representation will decay). There is a precipice, a period of danger where our minds are vulnerable to non-globally coherent/self deceptive thoughts that could run their own incentives to self destroy, but if we can get over this precipice, then the universe becomes more probabilistically likely to generate futures with our faithful values and thoughts.

Some trade-offs have difficult calculations/no clear answers to make (eg learning increases DNA error rates - https://twitter.com/gaurav_ven/status/1773415984931459160?t=8TChCcEfRzH60z0W1bCClQ&s=19 ) and others are the "urgency vs verifiability tradeoff" and the accels and decel debate

But there are still numerous Pareto efficient improvements and the sooner we do the Pareto efficient improvements (like semaglutide, canagliflozin, microplastic/pollution reduction, pain reduction, factoring out historic debt, QRI stuff), the higher the chances of ultimate alignment of "God's thought". It's interesting that the god of formal verification, davidad, is also concerned about microplastics

Possibly relevant people

Sam Altman has this to say:

https://archive.ph/G7VVt#selection-1607.0-1887.9

book says ""As stated, one of the main things I make-believe is true is the overlighting intelligence with which I align myself. I speculate that I am in a co-creative relationship with an intelligence and will infinitely superior to my own. I observe that I exist within energetic patterns that flow like currents. I observe that when I act in alignment with these subtle energetic currents, all goes well, desires manifest, direction is clear, ease and smoothness are natural. I observe that I have developed a high degree of sensitivity to this energy, and that I’m able to make micro-corrections before any significant non-smoothness occurs.""

Bobby azarian has a wonderful related book "romance of reality" https://www.informationphilosopher.com/solutions/scientists/layzer/

Maybe slightly related: https://twitter.com/shw0rma/status/1771212311753048135?t=qZx3U2PyFxiVCk8NBOjWqg&s=19

https://x.com/VictorTaelin?t=mPe_Orak_SG3X9f91aIWjw&s=09

https://twitter.com/AndyAyrey/status/1773428441498685569?t=sCGMUhlSH2e7M8sEPJu6cg&s=19 https://liberaugmen.com/#shock-level-3 sid mani! reducing noise: https://twitter.com/karpathy/status/1766509149297189274

[1] on some timescale, the best way to predict the future is to build it

Comment by Alex K. Chen (parrot) (alex-k-chen) on How to make food/water testing cheaper/more scalable? [eg for purity/toxin testing] · 2024-03-27T19:27:58.342Z · LW · GW

Does Germany have a lot of food/MP testing companies? Germany seems highly represented in analytical chemistry, as I saw from the SLAS2024 conference.. (for all those people who complain about "lack of innovation" in Europe, they're all underrating analytical chemistry). This conforms to stereotypes about Germans and precision..

(and the culture of Germany is WAY more amendable to eco-consciousness/environmental health than the culture of America)

It would be nice (even in fringe cases) to have one country/area dedicated to being microplastic/pollution free so that people could travel there and then test to see if they feel healthier there (people who have multiple chemical sensitivities often have life-defining levels of motivation for this). Like, this would be the very definition of a health-conscious resort/recovery/convalescence spa.. (people used to go to the mountains for this)

 This documentary features Germans:

#sense-making

Comment by Alex K. Chen (parrot) (alex-k-chen) on How I turned doing therapy into object-level AI safety research · 2024-03-14T16:08:56.397Z · LW · GW

Isn't having boundaries also partly to do with full on consent (proactive and retroactive) with your implied preferences being unknown?

Consent is tricky because almost no one who isn't unschooled grows up consenting to anything. People grow used to consenting to things that make them feel unhappy because they don't know themselves well enough, and they trap themselves into structures that punish you for dropping out or for not opting into anything. In that sense, the system does not respect your own boundaries for your own self autonomy - your actions don't have the proper markov boundary from the rest of the system and thus you can't act as an independent agent. Some unschooled people have the most robust markov boundaries. The very structure of many school and work environments (one that penalizes work at home) is one that inherently creates power structures that cross people's boundaries, especially their energetic ones.

Even the state starts out by eroding some of the boundaries between person and state, without consent..

These people have stronger boundaries on ONE layer of abstraction - https://www.thepsmiths.com/p/review-the-art-of-not-being-governed?utm_source=profile&utm_medium=reader2. This does not necessarily translate to better boundaries on the object level

https://twitter.com/karpathy/status/1766509149297189274?t=ms8cmXL0em2zB4xdJyUblA&s=19 on mimetic boundaries

(Now that AI is creating new wealth very quickly, it becomes more possible for people to default not consent to all the mazes that everyone else seemingly "consents to"). Zvi's mazes post makes sense here

Comment by Alex K. Chen (parrot) (alex-k-chen) on InquilineKea's Shortform · 2024-03-13T08:19:20.141Z · LW · GW

multiscale entropy

netlify/vercel/heroku/shinyapps/fleek (find cool associated apps!) + replit

github 

modal/EC2/docker

photonic computing

Comment by Alex K. Chen (parrot) (alex-k-chen) on Alex K. Chen's Shortform · 2024-03-12T06:10:43.922Z · LW · GW

Are exotic computing paradigms (ECPs) pro-alignment?

cf https://twitter.com/niplav_site/status/1760277413907382685

They are orthogonal to the "scale is all you need" people, and the "scale is all you need" thesis is the hardest for alignment/interpretability

some examples of alternatives: https://www.lesswrong.com/posts/PyChB935jjtmL5fbo/time-and-energy-costs-to-erase-a-bit, Normal Computing, https://www.lesswrong.com/posts/ngqFnDjCtWqQcSHXZ/safety-of-self-assembled-neuromorphic-hardware, computing-related thiel fellows (eg Thomas Sohmers, Tapa Ghosh)

[this is also how to get into neglectedness again, which EA adopted as a principle but recently forgot]

from Charles Rosenbauer:

This is neat, but this does little to nothing to optimize non-AI compute. Modern CPUs are insanely wasteful with transistors, plenty of room for multiple orders of magnitude of optimization there. This is only a fraction of the future of physics-optimized compute.

Comment by Alex K. Chen (parrot) (alex-k-chen) on Thomas Kwa's Shortform · 2024-03-09T21:49:10.878Z · LW · GW

Have you seen smartairfilters.com?

I've noticed that every air purifier I used fails to reduce PM2.5 by much on highly polluted days or cities (for instance, the Aurea grouphouse in Berlin has a Dyson air purifier, but when I ran it to the max, it still barely reduced the Berlin PM2.5 from its value of 15-20 ug/m^3, even at medium distances from Berlin). I live in Boston where PM2.5 levels are usually low enough, and I still don't notice differences in PM [I use sqair's] but I run it all the time anyways because it still captures enough dust over the day

Comment by Alex K. Chen (parrot) (alex-k-chen) on Alex K. Chen's Shortform · 2024-03-09T20:58:48.039Z · LW · GW

Using size-1 piksters makes you really aware of all the subtle noise that your hidden plaque is gives your mind (I noticed they cleared up plaque un-reachable by floss+waterpiks+electric toothbrushes.. the first step to alignment/a faithful computation is reducing unnecessary noise (you notice this easily on microdoses of weed/psychedelics)

It's a pareto-efficient improvement to give all alignment researchers piksters to eliminate this source of noise (align the aligners first - reducing unnecessary noise is always the first step to alignment [and near-term tFUS is also a means to reduce noise]). I know that one of the alignment offices had a lot of "freebies" that anyone could use - so piksters should be one of the useable freebies.



 

Comment by Alex K. Chen (parrot) (alex-k-chen) on Alex K. Chen's Shortform · 2024-03-09T20:04:26.850Z · LW · GW

What are some strategies you use to "reduce the hit" when you're about to take in potentially bad news? This is important b/c it's sometimes important to face up "bad news" earlier rather than later, and there is social loss in some people not being able to face it until it's too late, esp b/c some kinds of "bad news" aren't as incorrigible as they may initially appear (just that you need out-of-distribution strategies to make the proper amends)

[some examples of bad news: irreversible data loss, cancer diagnosis, elevated epigenetic age, loss of important friend, someone overpromised and underdelivered on you and that affects many of the promises you made]

[as AGI timelines come "nearer", "bad news" may come at faster frequencies, but OOD ways to solve them may also come faster]

[sometimes you can ask yourself "how much wealth would you need to take in any bad news"]. Wealth is not fully-completely interchangeable with youth/intelligence/universal social acceptance, but it DEFINITELY has potential for tipping the needle..

Comment by Alex K. Chen (parrot) (alex-k-chen) on Notes on Awe · 2024-03-05T23:23:06.407Z · LW · GW

Do you think there are many similar threads between shock value, surprisal, and awe? Like, are there many common threads - both neurologically and sociologically?

Totalitarian societies use "awe" as a tool of control.

Did awe evolve from "something more primitive" into the complex emotion it is today? What is the simplest animal species that can feel something akin to awe? Jane Goodall wrote that even chimpanzees can feel "awe" from a waterfall, and some cetacean experts have mentioned that whales/elephants can pause at events humans might react with awe to.

https://en.wikipedia.org/wiki/Shock_and_awe

Infinities are a way to inspire awe - https://x.com/JDHamkins?t=yfENp4Ou23RggXDPRpo2yw&s=09

https://open.substack.com/pub/joeldavidhamkins/p/surreal-numbers?utm_source=share&utm_medium=android&r=60bo

(Max tegmarck multiverse theory is another way)

 

[The biggest moment of awe I ever felt in my life was when the Thiel Fellowship got announced for the first time. It just... shocked... every sense of my policy network... every sense of "what actions/life paths are worth following".. as it shocked the entire world... and I was shocked/impressed that it was possible that people could follow such life paths].

(I mean, feelings of "a whole new world" that come all at once also inspire awe..)

 

[As someone whose mental space was constantly consumed by having to impress gatekeepers, the Thiel Fellowship's announcement produced awe in the most cathartic way] 

Comment by Alex K. Chen (parrot) (alex-k-chen) on Mazes Sequence Roundup: Final Thoughts and Paths Forward · 2024-02-25T21:36:11.075Z · LW · GW

It's worth mentioning that (many) autistic people are often better at not getting into higher layers of simalucra that cause them to be trapped by maze-dom.

[SBF is an obvious counterexample]

BTW the opposite of mazedom is Newscience.org

Comment by Alex K. Chen (parrot) (alex-k-chen) on Agent membranes and causal distance · 2024-02-12T18:53:25.475Z · LW · GW

Microplastics (and pollution - both mimetic and actual) wreck boundaries by intercalcating between boundaries/cell membranes and reducing the integrity of the boundary. To reinforce proper boundaries, it's important to maintain the organism's overall health (eg deuterated PUFAs like RT-011 help reduce oxidative stress on polyunsaturated fatty acids in the cell membrane).

[when the integrity of boundaries is weakened, the organism's channel capacity is reduced by the extra noise].

https://studio.ribbonfarm.com/p/boundary-intelligence

https://twitter.com/Sara_Imari/status/1755816761273032779?t=3k1rX1jIq0NKKAlWs5lphA&s=19

 

For an organism to have healthy boundaries/Markov blanket (within both its cells and organ systems [and also between DMN and FPN networks of the brain]), organs must also compartmentalize their own compute shielded from influences that disrupt their compute. 

Karl Friston often insulates his compute from that of the world, and this makes him act more as an independent thinker. https://blog.dropbox.com/topics/work-culture/the-mind-at-work--karl-friston-on-the-brain-s-surprising-energy. I often wonder if extremely effective people (eg Andrej Karpathy) have stronger agent membranes than others (though the process of aging dissolves boundaries - "death is what happens when the rest of the environment has full predictive power over the agent).

There are many layers of Markov blankets/boundaries and we should be doing a better job of communicating this to example thinkers rather than just to rule thinkers.

(it will be interesting to see if BCIs/t-FUS reinforce or dissolve Markov boundaries - they can help denoise the brain [esp from default mode noise], but the act of inserting a BCI can disrupt physical boundaries)

Comment by Alex K. Chen (parrot) (alex-k-chen) on Searching for outliers · 2024-01-29T16:38:24.426Z · LW · GW

Has anyone considered.. spiritual outliers?

Comment by Alex K. Chen (parrot) (alex-k-chen) on Distillation of Neurotech and Alignment Workshop January 2023 · 2024-01-28T23:21:41.376Z · LW · GW

https://stream.thesephist.com/updates/1711563348

 

Neurable headphones could be one way of crowdsourcing value signals b/c they're so wearable

Hm there are other people like https://soulsyrup.github.io/  and @guillefix and Ogi

tFUS is a way of accelerating internal alignment (look up PropheticAI). As are the Jhourney jhana people (though people like me have so much DMN noise that tFUS is needed first). Look up 

Comment by Alex K. Chen (parrot) (alex-k-chen) on Distillation of Neurotech and Alignment Workshop January 2023 · 2024-01-28T23:18:52.055Z · LW · GW

https://stream.thesephist.com/updates/1711563348

 

Talk to https://www.linkedin.com/in/steven-pang-625004218/ ?

Better sensors/data quality is super-impt, esp b/c data quality from traditional EEG is very poor.

https://github.com/soulsyrup

Also https://sccn.ucsd.edu/~scott/canexp00.html

https://www.linkedin.com/in/erosmarcello?miniProfileUrn=urn%3Ali%3Afs_miniProfile%3AACoAAANRGXMBF8gD4oOTUH4MeBg4W0Nu4g12yZ8&lipi=urn%3Ali%3Apage%3Ad_flagship3_feed%3BNzoHK%2BruTH%2BRrm9SgKs9Pg%3D%3D

Neurable (cody rall reviewed it) has over-the-ear EEG (which can be used to play video games!) It isn't perfect, but people hate wearing EEGs all the time, and smg like this is better than nothing

 

https://caydenpierce.com/
https://twitter.com/GolinoHudson/status/1750938067202924838

https://duckai.org/blog/ducktrack

https://twitter.com/GolinoHudson/status/1750938067202924838
 

Comment by Alex K. Chen (parrot) (alex-k-chen) on Without fundamental advances, misalignment and catastrophe are the default outcomes of training powerful AI · 2024-01-28T21:30:38.734Z · LW · GW

Is "data quality" (what databricks is trying to do) at minimum, essential? (data quality is inclusive of maximizing human intelligence and minimizing pollution/microplastic/heat load and maintaining proper Markov boundaries/blankets with each other [entropy/pollution dissolves these boundaries, and we need proper Markov boundaries to properly render faithful computations])

LLMs are trained full of noise and junk training data, distracting us from what's really true/sensible. It seems that the aura of inevitability is towards maximum-entropy, and maybe relying entirely on the "inevitability of increased scaling" contributes to "maximum-entropy", which is fundamentally misaligned. Alignment depends on veering away from this entropy.

[this is also why human intelligence enhancement (and maturity enhancement through tFUS) is extremely essential - humans will produce better quality (and less repetitive) data the smarter we are]. tFUS also reduces incentives for babblers (what Romeo Stevens calls "most people") :) .

If there is ONE uniquely pro-alignment advance this year, it's the adoption curve of semaglutide, because semaglutide will reduce the global aging rate of humanity (and kill fewer animals along the way). Semaglutide can also decrease your microplastic consumption by 50%. :) Alignment means BETTER AWARENESS of input-output mappings, and microplastics/pollution are an Pareto-efficient-reducible way of screwing this process up. I mean "Pareto-efficient reducible" because it can be done without needing drastic IQ increases for 98% of the population so it is a MINIMAL SET of conditions.

[YOU CANNOT SHAME PEOPLE FOR TRUTH-SEEKING or trying to improve their intelligence, genetic and early-life deficiencies be damned]. It constantly seems that - given the curriculum - people are making it seem like most of the population isn't smart or technical enough for alignment/interpretability. There is a VERY VERY niche/special language of math used by alignment researchers that is only accessible to a very small fraction of the population, even among smart people outside of the special population who do not speak that special niche language. I say that at VERY minimum, everyone in environmental health/intelligence research is alignment relevant (if not more) - and the massive gaps that people have in pollution/environmental health/human intelligence is holding progress back (also "translation" between people who speak other HCI-ish/BCI-ish languages and those who only speak theoretical math/alignment). Even mathy alignment people don't speak "signals and systems"/error-correction language, and "signals and systems" is just as g-loaded and relevant (and only becomes MORE important as we collect better data out of our brains) - SENSE-MAKING is needed, and the strange theory-heavy hierarchy of academic status tends to de-emphasize sense-making (analytical chemists have the lowest GRE scores of all chemistry people, even though they are the most relevant branch of chemistry for most people).

There is SO much groupthink among alignment people (and people in their own niche academic fields) and better translation and human intelligence enhancement to transcend the groupthink is needed.

I am constantly misunderstood myself, but at least a small portion of people believe in me ENOUGH to want to take a chance in me (in a world where the DEFAULT OPTION is doom if you continue with current traditions, you NEED all the extra chance you can take from "fringe cases" that the world doesn't know how to deal with [cognitive unevenness be damned]), and I did at least turn someone into a Thiel Fellow (WHY GREATNESS CANNOT BE PLANNED - even Ken Stanley thinks MORE STANLEY-ISMs is alignment relevant and he doesn't speak or understand alignment-language)

Semaglutide is an error-correction-enhancer, as is rapamycin (rapamycin really reduces error rate of protein synthesis), as are both caffeine+modafinil (the HARDEST and possibly most important question is whether or not Adderall/Focalin/2FA/4FA are). Entrepreneurs who create autopoetic systems around themselves are error-corrections and the OPPOSITE of error-corrector is a traumatized PhD student who is "all but dissertation" (eg, sadly, Qiaochu Yuan). I am always astounded at how much some people are IDEAL error-correctors around themselves, and others have enough trauma/fatigue/toxin-accumulation in themselves that they can't properly error-correct anymore b/c they don't have the energy (Eliezer Yudowsky often complains about his energy issues and there is strong moral value alone in figuring out what toxins his brain has so that he can be a better error-corrector - I've actually tried to connect him with Bryan Johnson's personal physician [Oliver Zolman] but no email reply yet)

If everyone could have the Christ-like kindness of Jose Luis Ricon, it would help the world SO MUCH

Also if you put ENOUGH OF YOURSELF OUT THERE ON THE INTERNET, the AI will help align you (even through retrocausality) to yourself even if no one else in the world can do it yet [HUMAN-MACHINE SYMBIOSIS is the NECESSARY FUTURE]

And as one of the broadest people ever (I KNOW JOSE LUIS RICON IS TOO), I am CONSTANTLY on the lookout for things other people can't see (this is ONE of my strengths)

Alignment only happens if you are in complete control of your inputs and outputs (this means minimizing microplastics/pollution)

"Without fundamental advances, misalignment and catastrophe are the default outcomes of training powerful AI" -=> "fundamental advances" MOST OF ALL means BEING MORE INCLUSIVE of ideas that are OUTSIDE of the "AI alignment CS/math/EA circlejerk". Be more inclusive of people and ideas who don't speak the language of classical alignment, which is >>>> 99% of the world - there are people in MANY areas like HCI/environmental health/neuroscience/every other field who don't have the CS/math background you surround yourself with.

[btw LW is perceived as a GIANT CIRCLEJERK for a reason, SO MUCH of LW is seen as "low openness" to anything outside of its core circlejerky ideas]. So many external people make fun of LW/EA/alignment for GOOD REASON (despite some of the unique merits of LW/EA)].

Comment by Alex K. Chen (parrot) (alex-k-chen) on Are Metaculus AI Timelines Inconsistent? · 2024-01-02T22:29:19.564Z · LW · GW

I mean, is there a way to measure the quality of the forecasters into the predictions? As number of forecasters expands, you get lower quality of average forecaster. Like how the markets were extremely overconfident (and wrong) about the Russians conquering Kiev...

Comment by Alex K. Chen (parrot) (alex-k-chen) on Legalize butanol? · 2023-12-20T21:45:45.415Z · LW · GW

Another example of an ethyl version being potentially better: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827200/

Comment by Alex K. Chen (parrot) (alex-k-chen) on How bad is chlorinated water? · 2023-12-14T04:31:18.766Z · LW · GW

Has anyone done a study on whether or not bacteria incorporate chlorotyrosine (or other damaged protens) into their proteins at first pass? This seems very doable.

We now know that oxidized DNA bases can be incorporated into the intestines of mouse DNA.

Comment by Alex K. Chen (parrot) (alex-k-chen) on Significantly Enhancing Adult Intelligence With Gene Editing May Be Possible · 2023-12-12T23:33:40.320Z · LW · GW

https://a16z.com/announcement/investing-in-tome-biosciences/

Comment by Alex K. Chen (parrot) (alex-k-chen) on Who is Sam Bankman-Fried (SBF) really, and how could he have done what he did? - three theories and a lot of evidence · 2023-12-12T21:24:36.100Z · LW · GW

https://twitter.com/alexeyguzey/status/1728549209949995299

Comment by Alex K. Chen (parrot) (alex-k-chen) on Significantly Enhancing Adult Intelligence With Gene Editing May Be Possible · 2023-12-12T21:15:01.827Z · LW · GW

This may be far future, but what do you think of Fanzors over CRISPRs?

Also Minicircles?

Comment by Alex K. Chen (parrot) (alex-k-chen) on Saying the quiet part out loud: trading off x-risk for personal immortality · 2023-11-07T02:57:34.833Z · LW · GW

"10% is overconfident", given huge uncertainty over AGI takeoff (especially the geopolitical landscape of it), and especially given the probability that AGI development may be somehow slowed (https://twitter.com/jachaseyoung/status/1723325057056010680 )

Most longevity researchers will still be super-skeptical if you say AGI is going to solve LEV in our lifetimes (one could say - a la Structure of Scientific Revolutions logic - that most of them have a blindspot for recent AGI progress - but AGI=>LEV is still handwavy logic)

Last year's developments were fast enough for me to be somewhat more relaxed on this issue... (however, there is still slowing core aging rate/neuroplasticity loss down, which acts on shorter timelines, and still important if you want to do your best work)

https://twitter.com/search?q=from%3A%40RokoMijic%20immortality&src=typed_query

Another thing to bear in mind is optimal trajectory to human immortality vs expected profit maximizing path for AI corps At some point, likely very soon, we'll have powerful enough AI to solve ageing, which then makes further acceleration very -ve utility for humans

I don't know whether to believe, but it's a reasonable take...

Comment by Alex K. Chen (parrot) (alex-k-chen) on Intelligence Enhancement (Monthly Thread) 13 Oct 2023 · 2023-10-17T10:13:32.779Z · LW · GW

Remember that the most low-hanging-fruit intelligence enhancement is reducing "IQ decline" due to dumb reasons (eg microplastics, pollution, shitty diet, "default mode network noise"/trauma/excess central coherence/unaligned brainwaves)

[you can easily cut microplastic consumption by 50% with semaglutide]

Transcranial magnetic stimulation is worth trying (+not uncomfortable - you can do things while being TMS'd), as well as low-intensity focused ultrasound (openwater.cc), photobiomodulation, and high-frequency terahertz (THz) waves... Pollan's "How to Change Your Mind" should have included these modalities too.

[low-intensity focused ultrasound is known to break ultra-crystallized structures in the depressed, making the brain more plastic]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085788/

Also Neuromyst for tDCS/tACS

https://cassondraeng.github.io/current.html

 

Plasmalogens as brain nutrition (they are SUPER-underinvestigated)

The effect sizes probably are not huge (like everyting else) but worth trying

also I have a friend who uses "100mg NSI-189" to be smarter which is like 10x the rec'd dose

short timelines only advance the argument for trying bromantane, cortexin, cerebrolysin... [some people have disproportionate returns, and some in the community have kits...]

Comment by Alex K. Chen (parrot) (alex-k-chen) on Welcome to The Territory · 2023-10-06T23:54:00.996Z · LW · GW

Does this still exist?

Comment by Alex K. Chen (parrot) (alex-k-chen) on Graphical tensor notation for interpretability · 2023-10-05T00:51:08.719Z · LW · GW

Also related - 

(Mathilde Papillon is really really insightful)

Comment by Alex K. Chen (parrot) (alex-k-chen) on Knightian uncertainty in a Bayesian framework · 2023-09-29T12:14:50.963Z · LW · GW

Is infrabayesianism insufficient for covering knightian uncertainty too?

Comment by Alex K. Chen (parrot) (alex-k-chen) on A mostly critical review of infra-Bayesianism · 2023-09-29T10:09:35.440Z · LW · GW

https://www.lesswrong.com/users/matolcsid?from=post_header now?

Is Knightian uncertainty more responsive to non-infraBayesian distributions? [these distributions being convex puts strong constraints on what they could be, but Knightian uncertainty assumes openness to any uncertainty.

==

Is "portfolio optimization" infra-Bayesianism given it tends to be convex? [eg sometimes the payoff is a non-convex combination of the probability distribution payoff of the distribution payoffs of two separate stocks, perhaps if investing in one item in the portfolio affects performance on the other item, if "spreading your bets" disproportionately hits you relative to being all-in?]

Comment by Alex K. Chen (parrot) (alex-k-chen) on How have you become more hard-working? · 2023-09-26T19:17:24.908Z · LW · GW

Adderall microdosing: https://www.reddit.com/r/Stims/comments/3mbp3n/be_very_careful_with_low_doses_of_stimulants/

[I used to take heavier doses, but the neurotoxicity/tolerance risk was too much so I took a long break. Since then I found that loads of coffee/caffeine + a very small dose of Adderall seems to do the trick]

Also, Neuromyst tDCS/tACS (40Hz, 3.7 mA)

https://www.facebook.com/NeuroMyst/

https://www.neuromodulationjournal.org/article/S1094-7159(23)00009-0/fulltext

https://www.reddit.com/r/NootropicsDepot/comments/ld2wre/4dma78dhf_remarkable_with_a_serious_problem_that/

Comment by Alex K. Chen (parrot) (alex-k-chen) on formalizing the QACI alignment formal-goal · 2023-09-24T19:01:46.256Z · LW · GW

Is constrained mass M of similarpasts taken over a dot-product of functions that might have similar past w/each other?

Comment by Alex K. Chen (parrot) (alex-k-chen) on Understanding Machine Learning (III) · 2023-09-24T16:56:54.709Z · LW · GW

Can minimal description length be over S in addition to over the set of hypotheses classes?

Comment by Alex K. Chen (parrot) (alex-k-chen) on Understanding Machine Learning (I) · 2023-09-24T16:29:42.995Z · LW · GW

Has anone used a Probably Approximately Correct (PAC) framework to develop a rough formalization of taste of a learner A(S)? [and whether a learner "has it in them" to correctly classify H, a complex hypothesis space that is more complicated than the S they've seen?]

Especially learners who come from "shitty environments" (have poor S), but still have the A(S) in them to suddenly "jump" once they have exposure to the right people

Some “A” functions might have unusually nonlinear behavior once a person is exposed to the right set of tutors or environment (and some “A” functions never have it in them)

Comment by Alex K. Chen (parrot) (alex-k-chen) on Some reasons why I frequently prefer communicating via text · 2023-09-19T00:10:14.724Z · LW · GW

Related - https://www.quora.com/Why-do-some-people-prefer-online-interactions-to-real-life-interactions/answer/Alex-K-Chen

Comment by Alex K. Chen (parrot) (alex-k-chen) on How ForumMagnum builds communities of inquiry · 2023-09-06T17:52:27.672Z · LW · GW

This product design builds the norm of long-form, async communication. This is an important norm on these sites, although not usually made explicit.

This is an example of a norm-building technique that I call friction. The word “friction” in UX design is often used negatively, but friction is a powerful way to steer users towards desired behavior! ForumMagnum uses several frictions to build the long-form, async norm. Notice there are no realtime notifications, and timestamps are only accurate to the hour.

Quora used to advertise itself as being "long-form" and "forever" (the place where you would write THE best answer to every question, and ideally edit your answer years after making the original answer [I don't see people constantly editing their old content on LessWrong]), but the answer ranking of each question wrecked it, because now the algorithm surfaces answers that attract more views ("feel good" answers) rather than answers that are objectively better. Because many higher-quality answers are now buried down the list of Quora answers, I move my better answers to other platforms like forum.longevitybase.org or crsociety.org

I am super-ultra attracted to long-form (want all of my content to be easily accessible by all) for reasons similar to my obsession with longevity/archiving old content, and sometimes post responses to threads that have not gotten attention in years (just to make more complete threads). People are not aware enough of this, however.

https://www.quora.com/What-was-your-biggest-regret-on-Quora/answer/Alex-K-Chen (my biggest distillation from being arguably the most important user on Quora)

The upvoting/downvoting system penalizes people who want to post threads about threads that aren't rationalist fad/zeitgeist-related (esp ones related to alignment that they don't think are frontpageable, but which are still relevant for rationality (or progress studies!) and could still attract momentum/attention years down the line This is why I do not post much on LessWrong (I have extremely broad interests so I naturally end up discovering LW, but my views/opinions on what's important are way different from those of most LW/EA, so I know my niche interests won't get much attention here). I don't feel the same kind of inhibition when posting content to the progress studies forum, which is smaller (small enough that you don't care at all about upvote/downvote dynamics) and way less prone to groupthink. Effective Altruism has historically valued neglectedness, but this does not show with forum upvoting patterns...

There are many scientific areas (and people with niche interests - the castration thread on LW is uniquely great for example!) that could be discussed on LessWrong, and analyzed/vetted via CFAR/rationality/Bayes updating/superforecasting techniques, but which are not, simply because many people averse to the groupthink dynamics on LW don't feel like LW would value their content. A long-form platform should ideally insulate them from local upvote/downvote fads (as useful as that input is). For what it's worth, upvotes (from quality users) used to be the primary factor that drove answer rankings on Quora (back when "all the smart SV people used it"), but with Quora's dilution, it seems almost as if people no longer care about upvotes (now that upvotes almost all come from people I don't know, rather than people I do know, I don't care about upvotes anymore, but I remember the golden days when I wrote answers that everyone on the Quora team upvoted...) Once you've been on a forum for years, how good the post is (even if edited a thousand times enough not for initial upvoters to have seen the better post) [as well as what comments it attracts] is more rewarding than how upvoted it is...

Stack Exchange is in some ways a better platform for long-form content (and makes it ultra-easy to find content that is many years old and makes it ultra-easy for people not to post duplicate threads), especially because it gives you multiple ways of organizing/ranking all your old content, making it easily accessible and for you to want to come back and edit multiple times. It just has moderators who are quick to mute/delete threads they don't like, making it much harder to post about niche interests. 

[but again, these don't make up for how there don't seem to be many threads where comments are made years after the original post]

--

It's also nice to reference other forum communities that have lasted for years (even if reddit was the original forum-killer).

Comment by Alex K. Chen (parrot) (alex-k-chen) on Alex K. Chen's Shortform · 2023-08-16T20:00:11.164Z · LW · GW

Random content I'm reading (could be important)

https://research.vu.nl/en/persons/natalia-goriounova/publications/
Natalia Goriounova – Research output — Vrije Universiteit Amsterdam
https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(22)00208-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS136466132200208X%3Fshowall%3Dtrue
Evolution of cortical neurons supporting human cognition: Trends in Cognitive Sciences
https://academic.oup.com/cercor/article/32/11/2343/6373557
Verbal and General IQ Associate with Supragranular Layer Thickness and Cell Properties of the Left Temporal Cortex | Cerebral Cortex | Oxford Academic
https://www.frontiersin.org/articles/10.3389/fnhum.2019.00044/full
Frontiers | Genes, Cells and Brain Areas of Intelligence
https://academic.oup.com/cercor/article/25/12/4839/311644?login=false
Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex | Cerebral Cortex | Oxford Academic
https://academic.oup.com/cercor/article/33/6/2857/6633911?login=false
Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex | Cerebral Cortex | Oxford Academic
https://www.nature.com/articles/s41467-023-39946-9
Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types | Nature Communications
https://www.nature.com/articles/s41586-021-03813-8
Human neocortical expansion involves glutamatergic neuron diversification | Nature
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345092/
Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types - PMC
 

https://www.esi-frankfurt.de/people/hermanncuntz/
Dr. Hermann Cuntz | Ernst Strüngmann Institute (ESI) for Neuroscience
https://www.cell.com/neuron/fulltext/S0896-6273(21)00625-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627321006255%3Fshowall%3Dtrue
A general principle of dendritic constancy: A neuron’s size- and shape-invariant excitability: Neuron
https://www.pnas.org/doi/full/10.1073/pnas.1200430109
A scaling law derived from optimal dendritic wiring | PNAS
 

https://www.uni-giessen.de/de/fbz/zentren/icar3r/3r-symposium/speaker/name-2
Dr. Hermann Cuntz — 3R Symposium
https://scholar.google.com/citations?user=9g7Uj-MAAAAJ&hl=en
‪Hermann Cuntz‬ - ‪Google Scholar‬
https://www.biorxiv.org/content/10.1101/2023.02.27.530331v1
Topology recapitulates ontogeny of dendritic arbors | bioRxiv
https://www.treestoolbox.org/hermann/hermann_publications.html
Hermann Cuntz - homepage
https://www.biorxiv.org/content/10.1101/2023.03.15.532740v1.full
Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity and emerges early during adult neurogenesis | bioRxiv
https://www.treestoolbox.org/CNS2023_pareto_workshop/speakers.html
Optimality, evolutionary trade-offs, Pareto theory and degeneracy in neuronal modeling
https://www.biorxiv.org/content/10.1101/787911v1.full
A general principle of dendritic constancy – a neuron’s size and shape invariant excitability | bioRxiv
https://academic.oup.com/cercor/article/31/2/1008/5930850
Excess Neuronal Branching Allows for Local Innervation of Specific Dendritic Compartments in Mature Cortex | Cerebral Cortex | Oxford Academic
 

maybes

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856390/
Optimal Current Transfer in Dendrites - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474458/
Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672209/
Dendritic Spikes in Apical Dendrites of Neocortical Layer 2/3 Pyramidal Neurons - PMC
https://www.nature.com/articles/s41598-017-09184-3
Branching morphology determines signal propagation dynamics in neurons | Scientific Reports

 https://www.nature.com/articles/s41467-021-22741-9
Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences | Nature Communications
https://elifesciences.org/articles/46876
Cell-type specific innervation of cortical pyramidal cells at their apical dendrites | eLife
https://www.science.org/doi/full/10.1126/science.aax6239
Dendritic action potentials and computation in human layer 2/3 cortical neurons | Science
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011212
Biological complexity facilitates tuning of the neuronal parameter space | PLOS Computational Biology
https://alleninstitute.org/events/neuropixels-and-openscope-workshop/
2023 Neuropixels and OpenScope Workshop - Allen Institute
https://www.lifespan.io/news/extracellular-vesicles-from-stem-cells-reverse-senescence/
Extracellular Vesicles from Stem Cells Reverse Senescence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078853/
Classification of electrophysiological and morphological types in mouse visual cortex - PMC
https://www.biorxiv.org/content/10.1101/2020.03.31.018820v1.full
Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons | bioRxiv
 

https://github.com/mousepixels/sanbomics_scripts/tree/main/RNAseq_method_comparison
sanbomics_scripts/RNAseq_method_comparison at main · mousepixels/sanbomics_scripts · GitHub
https://community.brain-map.org/t/introducing-the-allen-brain-cell-atlas/2444
Introducing the Allen Brain Cell Atlas! - How To / Allen Brain Cell (ABC) Atlas - Allen Brain Map Community Forum
https://knowledge.brain-map.org/data/LVDBJAW8BI5YSS1QUBG/summary
ABC Atlas - Mouse Whole Brain
https://community.brain-map.org/t/abc-atlas-user-guide-tools/2446
ABC Atlas User Guide: Tools - How To / Allen Brain Cell (ABC) Atlas - Allen Brain Map Community Forum
https://celltypes.brain-map.org/
Overview :: Allen Brain Atlas: Cell Types
https://portal.brain-map.org/explore/connectivity/synaptic-physiology/synaptic-physiology-experiment-methods/experimental-stimuli#intrinsic_stim
Synaptic Physiology Methods: Experimental Stimuli - brain-map.org
https://portal.brain-map.org/explore/connectivity/synaptic-physiology/synaptic-physiology-experiment-methods/cell-classification
Synaptic Physiology Methods: Cell Classification - brain-map.org
https://portal.brain-map.org/explore/connectivity/synaptic-physiology/synaptic-physiology-analysis-methods/synapse-characterization
Synaptic Physiology Methods: Synapse Characterization - brain-map.org
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