LessWrong 2.0 Reader

Thanks for posting Mako. I even mention Effective Altruism/Longtermism at one point in the video!

If your acceptable lower limit for basically anything is zero you wont be allowed to do anything, really anything. You have to name some quantity of capabilities progress that’s okay to do before you’ll be allowed to talk about AI in a group setting.

"The optimal amount of fraud is non-zero."

Looks relevant to me on a skim! I'd probably want to see some arguments in the submission for why this is useful tooling for mech interp people specifically (though being useful to non mech interp people too is a bonus!)

Originally I felt happy about these, because “mostly agreeing” is an unusually positive outcome for that opening. But these discussions are grueling. It is hard to express kindness and curiosity towards someone yelling at you for a position you explicitly disclaimed. Any one of these stories would be a success but en masse they amount to a huge tax on saying anything about veganism, which is already quite labor intensive.

The discussions could still be worth it if it changed the arguer’s mind, or at least how they approached the next argument. But I don’t get the sense that’s what happens. Neither of us have changed our minds about anything, and I think they’re just as likely to start a similar fight the next week.

May I ask what your motivation was when you decided to spend your time on the aforementioned discussions? Were you hoping to learn something or to persuade the other, or both?

It sounds to me as though the solution here is to be more cautious before spending time arguing. Sometimes (often) it is IMO wiser to cut your losses and stop replying.

In the war example, wars are usually negative sum for all involved, even in the near-term. And so while they do happen, wars are pretty rare, all things considered.

Meanwhile, the problem with AI development is that that there are enormous financial incentives for building increasingly more powerful AI, right up to the point of extinction. Which also means that you need not some but all people from refraining from developing more powerful AI. This is a devilishly difficult coordination problem. What you get by default, absent coordination, is that everyone races towards being the first ones to develop AGI.

Another problem is that many people don't even agree that developing unaligned AGI likely results in extinction. So from their perspective, they might well think they're racing towards a utopian post-scarcity society, while those who oppose them are anti-progress Luddites.

A simplistic model of your metabolism is that you have two states:

1. The anabolic state which builds muscle and creates new cells.
2. The catabolic state which tears down dysfunctional structures and recycles your cells.

A common theme in scientific anti-aging is that you need to balance both states and that the modern life leads us to spend too long in the anabolic state (in a state of abundance, well fed, moderate temperature and not physically stressed). Anabolic interventions can lead to good outcomes in the short-term and quick results, but can potentially be bad long-term.

Cycling in this context would mean something like doing it every other day or every other week (what is optimal? probably no one knows). It could also mean timing it when you don't do fasts for those people who do alternate day fasting or other longer fasts. Fasting and calorie restriction would be typically catabolic activities.

You mean in a positive or negative way? Harmful? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615097/ , and/or useless? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447210/ 

I haven't paid attention to this recently (I have small kids, so we need to cook anyway), but I think it is magnesium and calcium -- they somehow interfere with each other's absorption.

Just a random thing I found in google, but didn't read it: https://pubmed.ncbi.nlm.nih.gov/1211491/

(Plus there is a more general concern about what other similar relations may exist that no one has studied yet, because most people do not eat like "I only eat X at the same time as Y, mixed together".)

Can you say more? What are "anabolic effects"? What does "cycling" mean in this context?

David Sinclair mentioned in a podcast that he is also a bit worried about the long term anabolic effects of the retinoids. He suggested cycling it, possibly synchronized with other catabolic cycling such as fasting.